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Antivaccinationists in England, other parts of Europe, and the United States were active in publishing, speaking, and demonstrating about their objections to vaccination.

The New York City Board of Health told the Health Department to devise a plan to ensure the purity and potency of diphtheria antitoxins sold in the city. Congress passed "An act to regulate the sale of viruses, serums, toxins, and analogous products," later referred to as the Biologics Control Act (even though "biologics" appears nowhere in the law). Public Health Service to oversee manufacture of biological drugs.

Thomas Jefferson himself was a great proponent–particularly of the smallpox vaccination, which he received shortly after its development in 1796.

Those parents have opted out of the medical practice: their children have not received the required tetanus, diphtheria, and pertussis (whooping cough) vaccine, commonly known as TDa P.

By the end of the year, magistrates had issued more than 200,000 vaccination exemptions.Plait, despite his personal libertarian leanings, explains: In some areas, public school authorities have mandated that students be vaccinated for various diseases, and that of course can run afoul of parents’ beliefs.I’ve wrestled with this problem for a while, and I eventually came to the conclusion that a parent does not have the right to have their child in a public school if that child is unvaccinated … The societal aspect Plait references is “herd immunity.” Herd immunity is “when a critical portion of a community is immunized against a contagious disease, [so] most members of the community are protected against that disease because there is little opportunity for an outbreak.” David Perry frames the problem this way: Happily, in a population of vaccinated people, infectious but preventable diseases have trouble spreading even to the immunocompromised.“Those who had no choice” refers to individuals born with immunodeficiency disorders.The development and growing use of smallpox vaccine in the early 1800s triggered the establishment of vaccination mandates, especially for children.

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